More importantly, it is worth noting that the activation of Nrf2 can further block the NF-κB signal [24], forming an “anti-oxidation-anti-inflammatory” positive feedback loop, thereby breaking the vicious interaction of oxidative damage, lipid metabolism disorders and inflammatory response, and providing a multidimensional intervention strategy for metabolic liver disease. The gene discussed is NFE2L2; the disease is Disorder of lipid metabolism.