We also examined human plasma samples from patients with CRC as compared to normal controls and noticed that in addition to the more abundant full-length MATα2 in plasma samples of CRC patients, there is a truncated forms of MATα2 (MATα2-t) that is also at a much higher levels as compared to normal healthy controls (Fig. 6C). The gene discussed is MAT2A; the disease is colorectal carcinoma.