Third, benchmarking against hepatocellular carcinoma (HCC) reinforces plausibility: classic AFP‐plus‐size nomograms in HCC achieve AUCs around 0.78, and deep‐learning radiomics may climb beyond 0.85 [22, 23]—values congruent with the upper bound we observe for a purely laboratory‐based tool. This evidence concerns the gene AFP and hepatocellular carcinoma.