Then the results of KEGG enrichment analysis on these 48 down-regulated genes were enriched for Jak-STAT signaling pathway, pertussis, cytokine-cytokine receptor interaction, rheumatoid arthritis, IL-17 signaling pathway, viral proteins interaction with cytokine and cytokine receptor, c-type lectin receptor signaling pathway, Yersinia infection, vascular smooth muscle contraction, influenza A, and other signaling pathways (Fig. 2G). This evidence concerns the gene CLEC4D and rheumatoid arthritis.