TP53 and viral infectious disease: Consistent with these findings, GO and KEGG pathway analyses of CCNE1high vs. CCNE1low ECs revealed shared enrichment of proliferative pathways (cell cycle, DNA replication, and p53 signaling) and subtype-specific differences, including T-cell receptor/viral infection pathways in SCC versus cell adhesion and extracellular matrix remodeling in ADC (Fig. 4E and F).