To overcome limitations of prior studies, including insufficient sample sizes for robust statistical inference, ancestry heterogeneity or Eurocentric cohort bias, and fragmented assessments of lysosomal genes contributions, we leveraged large-scale cohorts of genotyping data from GP2 (Global Parkinson’s Genetics Program) and investigated association of common and rare variants in lysosomal related genes (TMEM175, SCARB2, CTSB and GBA1) with PD across ten populations. Here, TMEM175 is linked to Parkinson disease.