ESR1 and breast cancer: SUMOylation of ZNF282 augments its coactivator function through enhanced binding interactions with ERα and the coiled-coil coactivator (CoCoA), leading to transcriptional upregulation of ERα target genes (TFF1/pS2, GREB1, PgR, and CTSD) and consequent stimulation of estrogen-dependent breast cancer cell proliferation [14].