HMGCS2 and colorectal carcinoma: For instance, novel lncRNA LOC101928222 synergizes with insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) to stabilize 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) mRNA through an m6A-dependent pathway, resulting in enhanced cholesterol synthesis and, ultimately, the promotion of CRC development [40].