Another research indicated that LncRNA-HMG binds to p53 and induces the upregulation of solute carrier family 7 member 11 (SLC7A11) and vitamin K epoxide reductase complex subunit 1L1 (VKORC1L1) expression, thereby inhibiting ferroptosis in CRC and promoting chemotherapy resistance [41]. This evidence concerns the gene TP53 and colorectal carcinoma.