Ring Finger Protein 14 (RNF14) is an E3 ubiquitin ligase involved in protein degradation and signaling regulation in CRC, RNF14 overexpression is associated with poor prognosis and contributes to tumor growth by modulating key oncogenic pathways, such as Wnt/β-catenin signaling [5]. This evidence concerns the gene RNF14 and colorectal carcinoma.