E2F1 and esophageal squamous cell carcinoma: Mechanistically, ZNF282 functions as a critical coactivator of E2F transcription factor 1(E2F1), transcriptionally upregulating the expression of cyclin A1 (CCNA1) and cell division cycle 6 (CDC6), thereby driving malignant progression in esophageal squamous cell carcinoma (ESCC) [13].