PYCR2 and colorectal carcinoma: Through integrated transcriptomic and clinical analyses, we identified PYCR2 as consistent downstream targets and most relevant effector of LINC02878, indicating that LINC02878 may regulate proline metabolism in CRC through PYCR2, which is consistent with previous reports highlighting the role of PYCR2 as a critical metabolic enzyme in cancer progression [44].