The rearrangement was verified in tumor cells using FISH break-apart probe for NTRK2. RNA-sequencing revealed two in-frame TRIM24::NTRK2 transcript isoforms; exon 12–14 and exon 12–13, both including an intact tyrosine kinase domain (TKD, Supplementary Fig. 1). Here, TRIM24 is linked to neoplasm.