For instance, Gao et al. (2024) engineered polymeric nanoparticles that exploit tumor acidosis for on-demand drug release, while Chen et al. (2025) developed pH-activated micelles for co-delivery of doxorubicin and siRNA in HER2+ models both demonstrating that microenvironmental triggering is a robust strategy for precision therapy2324. The gene discussed is ERBB2; the disease is neoplasm.