Given that sensory nerves predominate over TH+ and VAChT+ fibers in the HNSCC milieu and that Cav2 expression is chiefly associated with these sensory nerves, we generated AdvCreCav2f/f mice by breeding Cav2f/f with Adv-Cre mice (Fig. 4G). This evidence concerns the gene SLC18A3 and head and neck squamous cell carcinoma.