To further evaluate the in vivo effects of Cav2 on the OXPHOS phenotype of HNSCC, we performed multicolor immunohistochemical staining to assess the expression of OXPHOS-related markers (SDHB, UQCRC, ATP5A1, NDUFB8) in tumors from the mouse models presented in Fig. 4. The gene discussed is NDUFB8; the disease is head and neck squamous cell carcinoma.