Our continued research on the influence of Cav2+ TGs on HNSCC cell resistance to platinum-based chemotherapeutics revealed that SCC15 cells co-cultured with Cav2+/+ TGs displayed reduced apoptosis following cisplatin treatment compared to SCC15 cells co-cultured with Cav2-/- TGs. Here, CAV2 is linked to head and neck squamous cell carcinoma.