To elucidate the impact of host-expressed Cav2 on neoplastic progression, murine-derived HNSCC cell lines MOC1 and MOC2 were orthotopically transplanted into wild-type and Cav2-deficient (Cav2-/-) C57BL/6 mice (Fig. 4A). Here, CAV2 is linked to head and neck squamous cell carcinoma.