USP13 and neoplasm: We also found that USP13 depletion delayed tumor growth in both immunocompetent C57BL/6 mice and immunodeficient NCG mice transplanted with Hepa 1–6 tumor cells; however, the effect was weaker in the NCG mice, underscoring the importance of intact adaptive immunity in the efficacy of USP13 depletion (Fig. S3A–C).