AGXT and primary hyperoxaluria type 1: The most common pathogenic AGXT variant (c.508G>A [GenBank: NM_000030.3]; [Gly170Arg]; rs121908529) is found in 24%–37% of PH1 patients, is associated with significant catalytic activity, and leads to peroxisome to mitochondrion mistargeting [7, 8].