Accordingly, we induced tau and αSyn inclusions concurrently in WT mice through the intracerebral coinjection of AD-tau and αSyn PFFs (Luk et al., 2012b; Ardah et al., 2014; Bassil et al., 2021) and asked whether ACY-738 might reduce one or both of these neurodegenerative pathologies 3 months after brain seeding. Here, MAPT is linked to Alzheimer disease.