MAPT and Alzheimer disease: The ability of ACY-738 to affect tau and/or αSyn inclusions in vivo was assessed in a model in which both of these pathologies were induced concurrently through the intracerebral injection of AD-tau and αSyn PFFs into WT mice (Luk et al., 2012b; Guo et al., 2016; Bassil et al., 2021).