Cognitive testing was not undertaken with the study mice, since there have been no reports of measurable learning and memory deficits in WT mice 3 months after intracerebral injection of AD-tau or αSyn PFFs, consistent with the absence of overt neuronal loss in the mice at this postinjection time (Guo et al., 2016; Nouraei et al., 2018). This evidence concerns the gene MAPT and Alzheimer disease.