SCP2 and delirium: The SCP2 is an intracellular lipid transfer protein that facilitates fatty acid transport and mitochondrial β-oxidation.44The accumulation of 3-hydroxyoctanoate, a medium-chain fatty acid β-oxidation intermediate, in CSF may reflect impaired mitochondrial function.45Given neurons' high dependence on mitochondrial energy production,22, 23this disruption could contribute to delirium development through compromised synaptic transmission and cellular homeostasis.