MAPT and Alzheimer disease: Recent studies suggest that the deposition of β-amyloid protein in the brain will be in the basal forebrain, a structure involved in sleep regulation and implicated in the progression of Alzheimer's disease.30, 31Alternatively, these initial disruptions in sleep architecture may be the impetus for the development of the disease, generating disruptions in the glymphatic clearance of waste, which would lead to further accumulation of β-amyloid plaques and tau tangles.31, 32, 33