Four of these used the POETIC framework: Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid-2); Provision of Psychological Support to People in Intensive Care (POPPI), Sedation AND Weaning in CHildren (SANDWICH), and Alpha-2 agonists for sedation to produce Better outcomes from critical illness (A2B). Here, PSMA2 is linked to ventilator-associated pneumonia.