In support of this, Jaquet et al. [40] reported a U-shaped relationship between serum adiponectin levels and insulin resistance in young adults with LBW, which consistent with Evagelidou et al., was interpreted to indicate a compensatory and somewhat disproportional increase in circulating adiponectin levels in LBW during the peripubertal period. This evidence concerns the gene ADIPOQ and Insulin resistance.