They found that alternatively activated (M2-like) interstitial macrophages mediated viral clearance via activation of CD8 + T cells on day 7 p.i. In our SARS-CoV-2 breakthrough infection model, we also observed an M2-like phenotype among interstitial macrophages and monocytes including high expression of Arg1, Chil3, and Ccl24 (Fig 6), similar to the phenotype from the helminth model. The gene discussed is CD8A; the disease is infection.