CD4 and Parkinson disease: This axis is particularly critical in PD pathogenesis: elevated XIST expression in peripheral CD4+ T cells strongly correlates with H3K27me3 enrichment at the CD4 locus, driving aberrant Th1/Th17 polarization [5,7].” In addition, there is a lack of research on two lncrnas in Parkinson’s disease (INE1 and NORAD).