Conversely, traits associated with an increased risk of osteoporosis included higher counts of CD33+ HLA-DR+ myeloid cells, elevated percentages of NKT cells among T cells, increased HLA-DR expression in hematopoietic stem cells and monocytes, and elevated CD14 expression in CD33^dim HLA-DR+ CD11b+ cells. The gene discussed is ITGAM; the disease is osteoporosis.