Patients in the VHR group (n=12), in comparison with the HR group (n=50), were older (64.5 vs. 46.6 years, p=0.001), with longer duration of T1D (36 vs. 25 years, p=0.001), had higher NT-proBNP levels (median of 157.77 vs. 42.8 ng/l, p=0.007), more frequent arterial hypertension (75 % vs. 32 %, p=0.009), lower total cholesterol (4.28 vs. 4.78 mmol/l, p=0.048) and a higher use of statin therapy (83 % vs. 32 %, p=0.002) (Table 2). The gene discussed is NPPB; the disease is Hypertension.