Furthermore, aberrant urinary SerpinA3 excretion has been observed in patients with diverse kidney pathologies, including lupus nephritis, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated-vasculitis, glomerulosclerosis, and diabetic nephropathy, the latter being a common complication of T2D. The gene discussed is SERPINA3; the disease is type 2 diabetes mellitus.