IL6 and Insulin resistance: Compared with those in WT + HFD mice, normal systemic IL-6 levels in KO + HFD and KO + D2 mice, suggest that SerpinA3k deficiency mitigates systemic inflammation; this is critical, as inflammation is a major driver of insulin resistance and diabetic complications [4, 12] Intesryingly, SerpinA3k expression was significantly reduced in the liver, renal, and adipose tissues of WT + HFD and WT + D2 mice (Figs. 4 A and 5C and 6A).