Furthermore, overexpression of IGF-1 in neural progenitors in a medulloblastoma mouse model (Ptc±;Igf1Tg) switched IGF-1 role to favor proliferation over differentiation in the first postnatal weeks promoting brain overgrowth and EGL lesions, leading to the activation of abnormal development pathways that promote metastasis in the cerebellum [79]. Here, IGF1 is linked to medulloblastoma.