Isolated case reports and small series have suggested a possible association between TTN missense variants and arrhythmogenic right ventricular cardiomyopathy (ARVC) [51, 52], hypertrophic cardiomyopathy (HCM) [53, 54] and restrictive cardiomyopathy [55]. Here, TTN is linked to Arrhythmogenic right ventricular dysplasia.