INS and type 1 diabetes mellitus: Therefore, even if both the Type 1 and Type 2 diabetes patients present with hyperglycemia, the overproduction of adiponectin under Type 1 diabetes (possibly as a compensation to enhance the insulin sensitivity) may be exerting a suppressive effect on the growth of UM cells and possibly the missegregation of chromosome 3 by preventing nucleolar enlargement, contributing to smaller lesions with a lower incidence of monosomy 3.