PHETA1 and rheumatoid arthritis: In particular, the analyses identified a few significant genes shared with V1, including PHETA1, a gene involved in endosomal trafficking that may play a role in regulating membrane dynamics by interacting with the inositol polyphosphate 5-phosphatase OCRL-1 enzyme,41 and MAPKAPK5-AS1, a long noncoding RNA (lncRNA) gene that has a role in cancer and rheumatoid arthritis.42