The 10‐year risk of progressing to stage 3 T1D for children with single islet autoantibody positivity has been found to be lower (14.5%), but for those with insulinoma‐associated antigen 2 autoantibody (IA‐2A) positivity, the risk is significantly higher (40.5%) than for those with glutamic acid decarboxylase autoantibody (GADA) positivity (12.9%) or insulin autoantibody (IAA) positivity (13.1%) [9]. This evidence concerns the gene INS and type 1 diabetes mellitus.