To further validate the biological relevance of the seven candidate psoriasis marker genes identified in this study, we systematically reviewed and integrated research evidence from the past 5 years concerning the expression and functional regulation of BIN2, CAPN12, CXXC5, KLRC1, KLRD1, PRF1, and SLFN5 in CD4+ T cells. The gene discussed is PRF1; the disease is psoriasis.