Although there were no changes in the expression levels of granzyme B, TRAIL and FasL, the overall increase in the tumor-infiltrating CD8+ T cell subset, induced by rhCD137L-MSNs and ure-MSNs, resulted in a proportional increase in the number of CD8+ T cells expressing granzyme B, TRAIL and FasL, in both C666 and C666-CD137 tumors. The gene discussed is TNFSF10; the disease is neoplasm.