The expression and secretion of FGF19 can be activated by HMGA1, serving as a "molecular switch." FGF19 not only provides signals to induce rapid growth and invasion of tumor cells into surrounding tissues but also collaborates with HMGA1 to form a dense, fibrous, scar-like wall around tumor cells, preventing treatment from reaching them 37. The gene discussed is HMGA1; the disease is neoplasm.