In a study of TGF-β1-induced corneal dystrophy, CRISPR/Cas9 technology was utilized to establish a humanized mouse model of TGF-β1-linked Thiel-Behnke corneal dystrophy (TBCD) reproduced the corneal opacity phenotype observed in human patients 93 (Figure 7A). The gene discussed is TGFB1; the disease is Thiel-Behnke corneal dystrophy.