CIAO1 and neoplasm: Additionally, flow cytometry analysis of tumor immune cell composition (Figure S8F) revealed that CIA1 treatment significantly reduced the proportion of tumor-infiltrating macrophages (CD45+CD11b+F4/80+) (Figure 8M-N) and altered their polarization state: the proportion of M2-type macrophages (CD86−CD206+) was decreased, while M1-type macrophages (CD86+CD206−) increased (Figure 8O-P).