Notably, our findings on the reciprocal regulation of AMPKα2‐S491 and T172 phosphorylation in sarcopenia patients align with our previous observation that PAK4‐mediated AMPKα2‐S491 phosphorylation was elevated in the muscles of type 2 diabetic patients, while AMPKα‐T172 phosphorylation was suppressed [22]. This evidence concerns the gene PRKAA2 and type 2 diabetes mellitus.