In a review other biomarkers in neurosarcoidosis such as CSF sIL-2R, IL-6, CD4/CD8 ratio, neopterin, CCL2, S100B, absence of MRZ reaction, KL-6, serum IL-10, Amyloid A1 and plasma S100B are described as candidate biomarkers, but many lack specificity and their value in distinguishing neurosarcoidosis from other infectious or inflammatory diseases is yet unclear.42 This evidence concerns the gene CD4 and neurosarcoidosis.