GLP‐1RAs promote bone metabolism via Wnt/β‐catenin and Runx2 activation [100,103]; regulate RANKL/OPG balance [72,121]; inhibit LPS‐induced osteoclastogenesis [116]; enhance PDLSC osteogenesis under hyperglycemia/inflammation [87,119]. The gene discussed is TNFSF11; the disease is Hyperglycemia.