APS: antiphospholipid syndrome, ASA: atrial septal aneurysm, GPi: glycoprotein I (referring to β2​-glycoprotein I), IVUS: intravascular ultrasound, LVEF: left ventricular ejection fraction, MRI: magnetic resonance imaging, MRV: magnetic resonance venography, MTS: May-Thurner syndrome, NIHSS: National Institutes of Health Stroke Scale, PFO: patent foramen ovale, RoPE: risk of paradoxical embolism, TIA: transient ischemic attack. The gene discussed is GPI; the disease is autoimmune polyendocrinopathy.