AGT and acute kidney injury: Similarly, in our case, in addition to seizures early in the clinical course, our patient developed AKI with a peak serum creatinine level exceeding 4 mg/dL several days later. NSAID-induced AKI mainly results from prostaglandin inhibition, which removes the vasodilatory effect on renal arterioles and allows angiotensin II-mediated vasoconstriction [13].