Theoretically, this could contribute to systemic inflammation, vascular endothelial dysfunction, or vascular wall remodeling, processes implicated in aneurysm formation and rupture.[9–12] For instance, inflammatory mediators associated with periodontitis (e.g., IL-1β, TNF-α) may enhance matrix metalloproteinase activity, potentially weakening arterial walls. Here, TNF is linked to aneurysm.