Herein, we report a rare case of early onset GI-predominant AA amyloidosis without renal involvement in a patient with overlapping RA and human leukocyte antigen B27 (HLA-B27)-positive peripheral SpA (pSpA), suggesting that amplified IL-6–mediated inflammation and overlapping immune mechanisms may contribute to atypical organ involvement. Here, IL6 is linked to rheumatoid arthritis.