MAPK8 and autoimmune disease: IL-17 signaling pathway: IL-17 is a class of inflammatory factors closely related to autoimmune diseases and is closely related to inflammatory response and cytokine production after tissue injury.[28] Li Jingkun[29] found that JNK/c-JunI and p38/c-Fos pathways can activate the transcription factor AP-1 by L-17A and up-regulate the expression of COX-2 and the production of PGE2, thus playing an inflammatory effects in tissue injury.