While PSA remains the standard biomarker for post-surgical monitoring, its limitations in specificity often lead to uncertainty, necessitating more reliable biomarkers.[7] Liquid biopsy techniques, particularly miRNAs and ctDNA, have gained attention as promising alternatives.[8] These biomarkers provide a noninvasive means of detecting molecular changes associated with tumor recurrence, offering a more precise approach compared to PSA alone.[9]. Here, KLK3 is linked to neoplasm.