This discovery, coupled with the observation that autoantibodies and autoreactive T cells interact with autoantigen-containing human leukocyte antigens, representing 2 pivotal facets of autoimmunity, hints at the potential relevance of RPL9 to the biological mechanisms involving T cells, including immunoregulation and inflammation.[30] In the context of PPP2R1A, CD8 T cells exhibited the most significant positive correlation, while Neutrophils displayed the most pronounced negative correlation. This evidence concerns the gene CD8A and Autoimmunity.