TNF and Cowden disease: Biological drugs and, more specifically, anti-TNF drugs such as infliximab and adalimumab have proven efficient for the treatment of IBD in adults and children.[13] Notably, using biological drugs has improved pediatric inflammatory bowel disease outcomes, especially for adolescents.[14] EEN has been recommended as the first-line treatment for CD-induced remission in adolescents.[15] EEN can also induce CD remission without adverse effects.