Classical herbal components such as Sang Bai Pi and Xuan Shen clear lung heat, enrich Yin, and moisten the intestines, while adjunct herbs restore fluid balance and harmonize Qi.[12] Prior studies have demonstrated immunomodulatory effects of Xiebai San through PI3K–AKT pathway regulation, while Zengye Tang has been reported to modulate gut microbiota.[13–16] Our clinical results are consistent with these mechanistic observations, with XBZY producing significant improvements in cough resolution, syndrome-related symptoms, and quality-of-life scores. Here, AKT1 is linked to Cough.