MTOR and status epilepticus: It has been found that mTOR is a negative regulator of autophagy, and inhibition of the mTOR signaling pathway activates autophagy, regulates the balance between GABA and Glu to control epilepsy development, and serves to reduce the severity of seizures.[52] Another experiment investigated the dynamic changes of autophagy-related factor expression in the hippocampus of status epilepticus (SE) rats.