For example, in the process of controlling the BDNF/TrkB pathway, acupuncture at various points can treat epilepsy through multiple interventional pathways: acupuncture at the ST36 and LI11 points in rats can reduce neuronal apoptosis and restore the plasticity of the hippocampal neuronal synaptic structure to alleviate the cognitive impairment associated with epilepsy; and acupuncture at the HT7 points in rats can focus on decreasing the secretion of pro-inflammatory cytokines to alleviate seizures through anti-inflammatory effects. Here, BDNF is linked to Cognitive impairment.