However, CA-125 in peripheral blood of people with adenomyosis is abnormally elevated, and CA-125 can be adopted to assess the UV and the degree of residual lesions following surgery.[32,33] Dienogest plus GnRH-a can hinder or shrink the lesion tissue by reducing the level of CA-125 in adenomyosis, which is very important to suppress the recurrence following treatment. Here, MUC16 is linked to adenomyosis.