The horizontal pleiotropy analysis showed that in AR, BCAT1, CD109, CMYA5, CPA3, and CTSV had no horizontal pleiotropy; similarly, in CRSwNP, CD109, CPA3, CTSV, LAMB3, and LOXL4 also had no horizontal pleiotropy (Tables 3–6). This evidence concerns the gene LAMB3 and chronic rhinosinusitis with nasal polyps.