Among these, CTSV (OR = 0.6373, 95% CI = 0.5454–0.7446, P < .01) was found to be protective, while CD109 (OR = 1.1241, 95% CI = 1.0731–1.1775, P < .01), CPA3 (OR = 1.0841, 95% CI = 1.0406–1.1295, P < .01), LAMB3 (OR = 1.1341, 95% CI = 1.0637–1.2092, P < .01), and LOXL4 (OR = 1.1427, 95% CI = 1.0380–1.2581, P = .01) exhibited risk effects for CRSwNP (Fig. 2B). This evidence concerns the gene CPA3 and chronic rhinosinusitis with nasal polyps.