The activation of the NLRP3 inflammasome triggers the release of inflammatory cytokines, such as IL-1β and IL-18, through crucial proteins like caspase-1 and gasdermin D. These processes disrupt intracellular homeostasis and exacerbate inflammation.[69] Recent studies have identified key PRGs (AIM2, CASP5, and NLRP6) that are closely linked to the onset and progression of CRSwNP. Here, NLRP6 is linked to chronic rhinosinusitis with nasal polyps.