When combined, vitamin E and Se can help control allergic mediators, alleviate symptoms associated with rhinitis and asthma, reduce airway mucus secretion, and assist in the dilation of obstructed bronchi.[72] Additionally, the use of a multivitamin-mineral supplement containing Se has been proposed as adjunctive therapy for children with chronic or recurrent sinusitis.[73] Based on our findings, Se–CPA3 may represent a potential therapeutic approach for treating both AR and CRSwNP. This evidence concerns the gene CPA3 and rhinitis.