Previous research has also highlighted the significance of “cell adhesion molecule binding,” “cytokine receptor binding,” and “glucocorticoid receptor binding” in eosinophilic CRSwNP.[56] The 3.4 GSEA enrichment analysis in this study revealed that CPA3 is enriched in both AR and CRSwNP within the cell–cytokine receptor and hematopoietic cell lineage pathways, suggesting that CPA3 influences the pathogenesis of AR and CRSwNP through shared signaling mechanisms. The gene discussed is AR; the disease is chronic rhinosinusitis with nasal polyps.