The molecular mechanism by which exposure to violet light suppresses myopia and how expression of OPN5 in certain cell types in the eye is involved in this process is unclear, but may involve OPN5m-mediated increases in early growth response protein 1 (EGR-1) expression in the retina, which is observed in mice and chickens exposed to violet light [50, 65]. This evidence concerns the gene OPN5 and myopia.