PIEZO2 and neoplasm: A comprehensive meta-analysis revealed that PIEZO2 expression is positive association with lymphatic invasion (OR = 7.89, 95% CI: 3.96–15.73) but inverse relationships with invasion depth (OR = 0.17, 95% CI: 0.06–0.47), TNM stage (OR = 0.48, 95% CI: 0.27–0.87), and histological grade (OR = 0.40, 95% CI: 0.21–0.77) [17], reflecting its dual capacity to influence both tumor aggressiveness and differentiation states.