In contrast, GDX male AD mice did exhibit (1) reduced expression of the App transgene compared to sham-operated mice without altered macroH2A1 binding at the Thy1 gene and (2) a significant increase of macroH2A1 binding at the Psen1 gene without a change in Psen1 gene expression. The gene discussed is MACROH2A1; the disease is Alzheimer disease.