MAPT and Alzheimer disease: Transgenic human (h)Mapt was specifically expressed in cortical tissue of both male and female AD mice, irrespective of GDX, and was not expressed in WT mice [Fig. 8A, Genotype: F(1, 71) = 127.5, p < 0.0001, Treatment: F(1, 71) = 0.61, p = 0.44].