MACROH2A1 and Alzheimer disease: In contrast, macroH2A1 binding on mApp was reduced in AD females compared to WT females irrespective of GDX [Fig. 6B, Genotype: F(1, 39) = 4.59, p = 0.04, Treatment: F(1, 39) = 1.56, p = 0.22, Genotype × Treatment: F(1, 39) = 0.001, p = 0.97].