In contrast, in females, GDX increased mMapt expression in AD mice but not in WT mice (Fig, 6 C, q = 0.001 between AD sham-treated and AD GDX, q = 0.41 between WT sham-treated and WT GDX), consistent with macroH2A1 binding status. The gene discussed is MACROH2A1; the disease is Alzheimer disease.