MACROH2A1 and Alzheimer disease: There was a significant Genotype × Treatment interaction for macroH2A1 binding at mMapt for females [Fig. 6A, F(1, 16) = 9.71, p = 0.007], with GDX resulting in reduced macroH2A1 binding in AD females and increased macroH2A1 binding in WT females (Fig. 6A, q = 0.049 between AD Sham and AD GDX; q = 0.049 between WT Sham and WT GDX).